IL-17 and CD40 ligand synergistically stimulate the chronicity of diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Paradoxical Role of IL-17 in Progression of Diabetic Nephropathy.
Diabetic nephropathy (DN) is the most common cause of ESRD in the United States. Current standard of care for patients with DN can slow the progression of DN, but there are no effective therapies to halt progression of established DN. The lack of more effective therapies in established DN is in part because the underlying mechanisms involved in its progression are not fully understood. Therefor...
متن کاملInterleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells.
Renal allograft rejection is characterized by an influx of inflammatory cells. Interaction between infiltrating T cells and resident parenchymal cells might play an important role in the ongoing inflammatory response. The present study demonstrates that CD40L, a product of activated T cells, is locally expressed in kidneys undergoing rejection. Furthermore, during rejection, CD40 expression not...
متن کاملProinflammatory T cells and IL-17 stimulate osteoblast differentiation.
The local immune response is important to consider when the aim is to improve bone regeneration. Recently T lymphocytes and their associated cytokines have been identified as regulators in fracture callus formation, but it is not known whether T cells affect bone progenitor cells directly. The goal of this in vitro study was to investigate the role of different T cell subsets and their secreted...
متن کاملstudy the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats
nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...
15 صفحه اولEvidence for ligand-independent multimerization of the IL-17 receptor.
IL-17 and its receptor are founding members of a novel inflammatory cytokine family. To date, only one IL-17 receptor subunit has been identified, termed IL-17RA. All known cytokine receptors consist of a complex of multiple subunits. Although IL-17-family cytokines exist as homodimers, the configuration and stoichiometry of the IL-17R complex remain unknown. We used fluorescence resonance ener...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2017
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfw397